Hallmarks of aging

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Hallmarks of aging are distinctive features of the biological aging process. Such deteriorations have been enumerated with the goal of extending healthspan or lifespan: in Aubrey de Grey's Strategies for Engineered Negligible Senescence, and in the 2013 paper "The Hallmarks of Aging".

Strategies for Engineered Negligible Senescence

The Strategies for Engineered Negligible Senescence (SENS) are a classification of potential life extension therapies by the type of age-related damage they target. It was created by Aubrey de Grey in 2000 and published in his 2007 book Ending Aging. The seven types of damage listed are:

  1. Cell loss/atrophy
  2. Extracellular junk
  3. Extracellular crosslinks
  4. Cells resisting death
  5. Mitochondrial mutations
  6. Intracellular junk
  7. Nuclear mutations

The Hallmarks of Aging

"The Hallmarks of Aging" is a paper written by Carlos López-Otín, Maria Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer and published in 2013 in the journal Cell. The nine hallmarks presented are:

  1. Genomic instability
  2. Telomere attrition
  3. Epigenetic alteration
  4. Proteostasis loss
  5. Nutrient-sensing deregulation
  6. Mitochondrial dysfunction
  7. Cellular senescence
  8. Stem cell depletion
  9. Intercellular communication alteration

References

  • de Grey, Aubrey; Rae, Michael (2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. ISBN 0-312-36706-6.
  • López-Otín, Carlos; Blasco, Maria A.; Partridge, Linda; Serrano, Manuel; Kroemer, Guido (6 June 2013). "The Hallmarks of Aging". Cell. 153 (6): 1194– 1217. doi:10.1016/j.cell.2013.05.039.

External links