In 2011, Haywire started the annual Extreme Futurist Fest event in Los Angeles, California. The cyberpunk event combined talks on science and human enhancement, modeled after the TED conferences, with a number of live music performances and art installations. In 2012, Haywire described the event as "a 2 day arts and technology festival focusing on radical voices of the new evolution".
In January 2013, Haywire started a campaign to run for the board of directors of the transhumanist organization Humanity+, to which she was subsequently elected. She is also the founder of the all-female alternative music label machineKUNT Records, the "anti-conference" INSTED, the online magazine "Trigger Warning" (after trigger warnings), and the author of the autobiography Acidexia.
In 2019, Rachel Haywire runs for US Transhumanist Party candidacy. with the platform slogan "Beyond The Center". Which - according to this article - in her own words means remodeling the “edges” of the Left and the Right, while transcending the political Center."
"“My plan is to reallocate all of the funds that are going to non-violent drug offenders and sex workers in prison and needless overseas wars in order to make this happen,” Haywire argues, “I want to release all of these people from prison and bring all of our troops home once and for all.”"
“Transhumanism is for everyone. This is what my presidential campaign is about: Transhumanism for all.”
Haywire has variously described herself as a "transhuman separatist" or "transhumanist militant". Haywire was once associated with the far-right neoreactionary movement but says she left the movement in 2014. Haywire's Twitter feed has been cited by news outlets such as Newsweek, Glamour (magazine), Inquisitr, E!, and Breitbart News Network on the topics of social justice and domestic violence. At some point Haywire cleared her twitter feed, as they currently only go back to early 2018.
In 2011, Haywire started a crowdfunding campaign for her 'Extreme Futurists' project on the website Kickstarter. The project received over three hundred spam comments; in response, Kickstarter closed the project, and threatened to permanently ban Haywire from the Kickstarter platform. After Haywire's case attracted substantial media attention, Kickstarter apologized to Haywire, and said that it was not Kickstarter's policy to block projects which might be subject to abuse from third parties. However, Kickstarter did not update their community guidelines or terms of service in response to the incident, and these guidelines had no mention of comment spam or victims of cyberstalking. The technology magazine Digital Trends compared Haywire's harassment on Kickstarter to the harassment faced by feminist writer and cultural critic Anita Sarkeesian, who has also funded her advocacy projects through the website.
- Wauters, Robin (April 14, 2012). "Crowdfunding site Kickstarter accused of banning artist who received ‘too much comment spam’ [Updated"]. The Next Web. 
- ModelMayhem profile
- An Irreverent Guide To Transhumanism And The Singularity. Gizmodo. Retrieved 18 April 2016.
- Rachel, Haywire (August 15, 2014). "Breaking up with Neoreaction". Medium (website). 
- Bokhari, Allum (November 11, 2015). "Twitter Ridicules Campus SJWs with #NationalOffendACollegeStudentDay". Breitbart. . Retrieved 18 April 2016.