The Secret of NIMH
The Secret of NIMH (National Institute of Mental Health) is a 1982 animated science fiction movie directed by Don Bluth.
The movie is based on the 1971 novel by Robert C. O'Brien titled: Mrs. Frisby and the Rats of NIMH.
When Mrs. Brisby (who is known as Mrs. Frisby in the book) is forced to leave her home, she must seek the help of super-intelligent rats in order to do so. Her son is sick and cannot be moved without their assistance.
The main transhumanist feature to The Secret of NIMH is the super-intelligent rats who achieved their enhancements via scientific experiments that were conducted on them.
A sequel was made titled The Secret of NIMH 2: Timmy to the Rescue, however it received negative reviews and had no input from the creator of the original movie.