Transhumanist separatism is a fringe idea within the transhumanist political spectrum, advocating that transhumanists should form separate societies from mainstream society.
It can be considered a manifestation of the neo-reactionary movement, rejecting democracy and inclusivity.
When in 2010, Rachael Haywire and Jason Schoenecker wrote about "A Transhuman Separatist Manifesto", it provoked reactions of both interest in the future of relationships between enhanced and non-enhanced individuals, as well being described as 'a threat to H+' from various positions who rejected such an idea.
In later years, the concept of a separatist 'start up society' has been compared to ISIS, with scepticism directed towards ideas of libertarian sovereign compounds.
In the X-Men franchise, conflicts between the Magneto's seperatist Brotherhood of Mutants and Professor X's more inclusive approach set the backdrop of a number of conflicts in their fictional universe.